Something About Pepsin That You May Not Know
Pepsin is a digestive protease that is secreted by the gastric chief cell in the stomach and functions to break down the protein in the food into small peptide fragments. The main cell secretes pepsinogen, which is stimulated by gastric acid or pepsin to form pepsin. Pepsin is not produced directly by cells. The role of the stomach in digesting food means that the stomach can secrete gastric juice. The hydrochloric acid in the gastric juice activates the pepsin element, making it pepsin, and pepsin can digest the protein in the food. After the cow’s stomach is eaten into the human’s, the protein it contains is gradually digested by the stomach’s digestive juice. The stomach can digest all kinds of meat, but it is safe and sound. For this reason, Professor Deben, from the University of Michigan Medical School, has done an interesting experiment. He put the stomach removed from the human body into a large test tube, then added appropriate amount of hydrochloric acid and pepsin formulated according to the concentration of the normal human stomach, and placed the test tube at a constant temperature of 37°C. As a result, the stomach in the test tube was severely damaged and a considerable portion was dissolved. This experiment shows that the stomach cannot resist the digestion of hydrochloric acid and pepsin. Further research by Professor Deben shows that the stomach can be damaged, but it can also be easily repaired. It is this mechanism that performs an important function of protecting the surface of the stomach. He pointed out that the lipids on the cell membrane surface of the gastric parietal cells are very much related to resisting digestion. If detergents are used to remove the lipids on the cell surface, the gastric parietal cells will be attacked by acid. In addition, the gastric parietal cells are constantly renewed and the old cells constantly fall off the surface and are replaced by new ones in the tissues. Professor Deben estimates that about 500,000 cells are shed in the stomach every minute, and the gastric mucosa is updated every 3 days. Therefore, even if the inner wall of the stomach is damaged to a certain degree, it can be completely repaired within days or hours. So the stomach in the human body does not digest itself, but it will immediately renew itself after being digested to some extent. After years of research, some scientists have confirmed that the formation of gastric ulcers is the result of gastric acid and pepsin digestion; this self-digestion process is the direct cause of ulceration; digestion of gastric juice is an important factor in the formation of gastric ulcers.